OPTIMIZATION AND LEARNING UNDER UNCERTAINTY - A UNIFIED ROBUSTNESS PERSPECTIVE

Ph.DDOCTOR OF PHILOSOPH

Design and manufacturing of high precision roll-to-roll multi-layer printing machine : measurement and experiment

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.Cataloged from PDF version of thesis.Includes bibliographical references (p. 74-75).In 2008, a prototype machine demonstrating the application of roll-to-roll technology in micro-contact printing was developed. In this research, the prototype machine was upgraded by designing and machining a device that could fabricate a flat stamp with significantly less variance. The print roll wrapping system was reconfigured in order to capture the stamp with uniform force and good alignment. The motion control for the print roller and impression roller was also improved. In addition multi-layer printing with the updated machine was tested. This thesis focuses on the general design of the updated system and the measurement of key components of the systems as well as the print quality. Results demonstrate that the flat stamp can achieve the flatness of ±16 [micro]m with thickness of 1194 [micro]m; that the wrapping process can guarantee a print roller roundness error in the 20 [micro]m range; that the distortion of the print using the updated system is approximately 3.8. The multi-layer printing test did not achieve acceptable results owing to a lack of proper control of the machine. However, initial trials, achieved alignment errors of 1017 [micro]m along the printing direction and 113 [micro]m across the printing direction.by Wenzhuo Yang.M.Eng

AI for IT Operations (AIOps) on Cloud Platforms: Reviews, Opportunities and Challenges

Artificial Intelligence for IT operations (AIOps) aims to combine the power of AI with the big data generated by IT Operations processes, particularly in cloud infrastructures, to provide actionable insights with the primary goal of maximizing availability. There are a wide variety of problems to address, and multiple use-cases, where AI capabilities can be leveraged to enhance operational efficiency. Here we provide a review of the AIOps vision, trends challenges and opportunities, specifically focusing on the underlying AI techniques. We discuss in depth the key types of data emitted by IT Operations activities, the scale and challenges in analyzing them, and where they can be helpful. We categorize the key AIOps tasks as - incident detection, failure prediction, root cause analysis and automated actions. We discuss the problem formulation for each task, and then present a taxonomy of techniques to solve these problems. We also identify relatively under explored topics, especially those that could significantly benefit from advances in AI literature. We also provide insights into the trends in this field, and what are the key investment opportunities

Privacy-Preserving Aggregation in Federated Learning: A Survey

Over the recent years, with the increasing adoption of Federated Learning (FL) algorithms and growing concerns over personal data privacy, Privacy-Preserving Federated Learning (PPFL) has attracted tremendous attention from both academia and industry. Practical PPFL typically allows multiple participants to individually train their machine learning models, which are then aggregated to construct a global model in a privacy-preserving manner. As such, Privacy-Preserving Aggregation (PPAgg) as the key protocol in PPFL has received substantial research interest. This survey aims to fill the gap between a large number of studies on PPFL, where PPAgg is adopted to provide a privacy guarantee, and the lack of a comprehensive survey on the PPAgg protocols applied in FL systems. In this survey, we review the PPAgg protocols proposed to address privacy and security issues in FL systems. The focus is placed on the construction of PPAgg protocols with an extensive analysis of the advantages and disadvantages of these selected PPAgg protocols and solutions. Additionally, we discuss the open-source FL frameworks that support PPAgg. Finally, we highlight important challenges and future research directions for applying PPAgg to FL systems and the combination of PPAgg with other technologies for further security improvement.Comment: 20 pages, 10 figure

Salesforce CausalAI Library: A Fast and Scalable Framework for Causal Analysis of Time Series and Tabular Data

We introduce the Salesforce CausalAI Library, an open-source library for causal analysis using observational data. It supports causal discovery and causal inference for tabular and time series data, of both discrete and continuous types. This library includes algorithms that handle linear and non-linear causal relationships between variables, and uses multi-processing for speed-up. We also include a data generator capable of generating synthetic data with specified structural equation model for both the aforementioned data formats and types, that helps users control the ground-truth causal process while investigating various algorithms. Finally, we provide a user interface (UI) that allows users to perform causal analysis on data without coding. The goal of this library is to provide a fast and flexible solution for a variety of problems in the domain of causality. This technical report describes the Salesforce CausalAI API along with its capabilities, the implementations of the supported algorithms, and experiments demonstrating their performance and speed. Our library is available at \url{https://github.com/salesforce/causalai}

Deep Learning in Single-Cell Analysis

Single-cell technologies are revolutionizing the entire field of biology. The large volumes of data generated by single-cell technologies are high-dimensional, sparse, heterogeneous, and have complicated dependency structures, making analyses using conventional machine learning approaches challenging and impractical. In tackling these challenges, deep learning often demonstrates superior performance compared to traditional machine learning methods. In this work, we give a comprehensive survey on deep learning in single-cell analysis. We first introduce background on single-cell technologies and their development, as well as fundamental concepts of deep learning including the most popular deep architectures. We present an overview of the single-cell analytic pipeline pursued in research applications while noting divergences due to data sources or specific applications. We then review seven popular tasks spanning through different stages of the single-cell analysis pipeline, including multimodal integration, imputation, clustering, spatial domain identification, cell-type deconvolution, cell segmentation, and cell-type annotation. Under each task, we describe the most recent developments in classical and deep learning methods and discuss their advantages and disadvantages. Deep learning tools and benchmark datasets are also summarized for each task. Finally, we discuss the future directions and the most recent challenges. This survey will serve as a reference for biologists and computer scientists, encouraging collaborations.Comment: 77 pages, 11 figures, 15 tables, deep learning, single-cell analysi

Inflammatory factors and risk of meningiomas: a bidirectional mendelian-randomization study

BackgroundMeningiomas are one of the most common intracranial tumors, and the current understanding of meningioma pathology is still incomplete. Inflammatory factors play an important role in the pathophysiology of meningioma, but the causal relationship between inflammatory factors and meningioma is still unclear.MethodMendelian randomization (MR) is an effective statistical method for reducing bias based on whole genome sequencing data. It’s a simple but powerful framework, that uses genetics to study aspects of human biology. Modern methods of MR make the process more robust by exploiting the many genetic variants that may exist for a given hypothesis. In this paper, MR is applied to understand the causal relationship between exposure and disease outcome.ResultsThis research presents a comprehensive MR study to study the association of genetic inflammatory cytokines with meningioma. Based on the results of our MR analysis, which examines 41 cytokines in the largest GWAS datasets available, we were able to draw the relatively more reliable conclusion that elevated levels of circulating TNF-β, CXCL1, and lower levels of IL-9 were suggestive associated with a higher risk of meningioma. Moreover, Meningiomas could cause lower levels of interleukin-16 and higher levels of CXCL10 in the blood.ConclusionThese findings suggest that TNF-β, CXCL1, and IL-9 play an important role in the development of meningiomas. Meningiomas also affect the expression of cytokines such as IL-16 and CXCL10. Further studies are needed to determine whether these biomarkers can be used to prevent or treat meningiomas